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KMID : 0356919920250020394
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Korean Journal of Anesthesiology
1992 Volume.25 No. 2 p.394 ~ p.401
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Effects of Furosemide on Perioperative Serum Electrolytes and Osmolality during Transurethral Resection of the Prostate
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노운석
윤만모/박대팔/진선미/김봉일/이상화
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Abstract
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The purpose of this study was to prevent the dilutional effect of excessive absorption of irrigating solution by using furosemide intraoperatively during transurethral resection of the prostate.
Thirty patients, classified as ASA ps 2 or 3, were selected randomly and divided them into two groups as follows:
Group 1(N=15): Not-administrated furosemide(control group)
Group 2(N=15): Administrated furosemide(Experimental group)
All patients were premedicated with hydroxyzine(1mg/kg,IM) and were performed continuous epidural anesthesia with 2% lidocaine(1-1.5mg/segment). 5% Dsorbitols were used for irrigating solution, and Hartmen's solutions were given for maintenance
fluid.
And fixed the irrigating container to 60 cm in height from symphysis pubis. With the starting of operation 20mg furosemide was administrated to experimental group. The blood samples for serum Na+, k+, glugose and BUN were obtained at
preoperation,
10min, 20 min, 30 min after the stating of operation and immediate postoperative period, and serum osmolality and effective osmolality were calculated.
@ES The results were as follows:
@EN 1) The values of sodium concentration of control group were decreased significantly at 10min, 20min, 30min after the starting of operation and immediate postoperative period as compared with the preoperative value(p<0.05). But those of
experimental
group were not changed significantly.
2) The values of serum osmolality and effective osmolality were decreased significantly at 30min after the starting of operation and immediate postoperative period as compared with the preoperative value(p<0.05). But those of experimental group
were
not changed significantly.
These results show that the dilutional effect of excessive absorption of irrigating soution might be prevented by using furosemide intraopertively. So we would like to recommend the use of furosemide during TURP. Especially in patients with
congestive
heart failure or renal failure.
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KEYWORD
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TURP, Serum osmolality, Furosemide, Sodium
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